I still think that the interior of Prometheus looks very similar (though a bit cleaner) to the Nostromo. And the Transport looks very similar to the Colonial Marines' APC.
The stuff is a lot more sleek, that's for sure, but I'm willing to accept that. This is, after all, a modern day film taking a different approach. Plus, its simple to say that Prometheus, being a science ship, is better equipped than the Nostromo, a run-down mining ship. The differences in style aren't jarring enough to take me out of the film in any way.