I think so. The title of the movie, for starters, promises that there will at least be some type of Christian-mythology tie-in. My wife, the other day, remarked that the ship, being a colonization craft, felt a bit like Noah's Ark (replace the ocean of the Flood with the cosmic ocean—may be a stretch, but metaphors were Prometheus' strengths and since this is a sequel of that film...)—a doomed Noah's Ark, that is. Also, we know that there is
Spoiler
some sort of Engineer facility in this film
and that would lend itself to all kinds of religious/mythological/philosophical implications. In Prometheus, the Engineer facility contained the Ampule Room which lend itself to a sort of temple/cathedral within the cavernous complex—if it was purely a weapon's lab, then why the iconography behind a sealed room?
Now, I don't think that there will be any space-Jesus nonsense here, but there definitely may be some sort of tie-in to Lucifer/Prometheus via David AND/OR the Engineers. What do I mean by this? The more and more I think about it, I believe that the title of the first film, Prometheus, deals with stolen technology and the dichotomous concept of creation and creator. Also, there is motif in that film about repetition/cycles that is rooted in mythologies the world over (don't have a citation handy, but you will just have to take my word for it), and this is represented by the Engineers possibly stealing the bio-mechanical tech from an ancient race—or they themselves being the slaves of an ancient race—only for its creation—presumably us—turning back and stealing the technology from them (there is a loose version of this theme—Weyland Yutani always trying to harness an Alien sample—throughout the Alien series)Think of the Ouroboros (the snake biting its own tail).
Then, there is the concept of Lucifer (both in Prometheus (Lucifer has been compared to the Titan, loosely, by trying to put man on equal footing with God) and Covenant (previously Alien:Paradise Lost from the novel by John Milton detailing the fall of Lucifer)) which I believe to be embodied by David and you have a narrative ripe with symbolism of all kinds.
What do you think?