I'll be mildly perturbed if they kill off Amanda - they implied in some of the advance press that maybe she didn't live to a ripe old(er) age, didn't die at 66, maybe the company covered up the real details. I understand them playing that angle to keep the player in suspense, and I suppose it's a worthwhile idea.
I just am generally bored by recent prequels which implicitly require any protagonists to end up dead to preserve continuity - there are some of those that work, and I have no problem with a nihilistic ending, but it's gotten so old at this point over the last decade, including in some of the recent spate of new survival horror games where the protagonists all end up dead, insane, whatever - I've seen it all before. I hope they surprise me and let her live but throw a twist in somehow.