DC 1 was very similar to the early RE games - fixed camera, limited resources, limited inventory space, occasional puzzles. I think it was about comparable difficulty; one interesting aspect is that some of the most common weapons you have don't kill - they just incapacitate.
The inventory system is frustrating as hell, though. Instead of one network of storage boxes, you have three networks of storage bins - and at each location, the bin has to be unlocked with a plug. So, good luck storing medical supplies and hoping to get them later.
Key items do not take up space, though.