Nope.
Alien, showing us space truckers discovering an unknown alien spacecraft (let's remember it was an alien spacecraft back in '79) in some small planetoid in the ass-end of the universe (catch the reference!), wanted to tell us that the universe is unbelievably vast, how small we are compared to it and made us wonder what otherwordly horrors may lurk in the shadows of other systems and galaxies.
Prometheus seems to take this idea and completely turn the tables -- showing us the crew of the Prometheus ship bringing back what seems to be the head of an extraterrestrial thing, with all-but humanoid traits and proportions, and showing us said head exploding in a spray of green goo, revealing a perfectly humanoid head, wants to tell us the opposite: the universe is small, and in the ass-end of the universe the crew of the Prometheus does not meet something humanity has no link with -- something alien -- but something that seems to be deeply linked to us (quite obviously) and may even be our 'creators'.
Long story short, for what we know so far (we don't know if the actual film will be exactly like the trailers are showing it -- I'm working with the data supplied so far), the two films seem to have polar-opposite philosophies.