I would not define it as new and fresh to be honest. From what we know so far,
Prometheus is using quite the old sci-fi tropes we've already seen before, and injecting them into the Alien universe. Maybe that is the entire point and intention -- of using said old tropes in Scott's style, but it's nothing really fresh or never heard of before.
Sure as hell a whole new audience will be brought -- sciento guys will be all over the film if it is exactly like what it's been suggested to be so far.
This does not mean I am not looking forward to the film, however.