I know this will never happen, but I want to see the universe expanded into a larger setting, with more races. More of a Mass Effect/Warhammer 40K/Star Wars/Starcraft/Star Trek amount of universe detail.
Note I don't mean for it to be like the TONE or CONTENT of those franchises, just the SCOPE of the franchise.
I'd want a really dark universe. Lots of dead races, left over weapons and derelicts, horrible creatures from the far corners of the galaxy. Planets rendered uninhabitable. Entire planets that are rendered death traps by still active ancient weapons of war. I want to see signs of the terrible legacies of our galaxies species both dead and alive. Terrifying alien intelligences with inscrutable agendas. This could be the AvP universe.
Aliens, Predators, and Jockeys all fit perfectly into my little dark movie universe fantasy in my head.