They don't stand much of a chance, maybe even with weapons in close combat. though still they can defeat the hunters in some way, maybe unknown to the pred. If that would occur, the tables could be turned with a shot from the pc. This chance gets dropped as the pred detaches his weapon. And again, I don't think At knew what exactly he was dealing with. First he was trying to find out, and when he saw he 'won' got cocky. And he died.
Of course I'm not saying a human would defeat a pred in hand to hand combat. Only the 'Chuck'.