Love the idea of a future setting; for me, I hope there are no Alien universe Easter eggs or attempt to tease a future AvP (but instead is simply used as a proof of concept with the setting).
I think I'd like to see the type of future seen in 'Dredd' - not cyberpunk or flying cars etc, just run down, dilapidated crime-ridden mega structures surrounded by the badlands, its own sort of cursed-Earth post-nuclear war or whatever, with scorching sun from climate change making it a really desirable hunting ground (playing on the "only in the hottest years this happens" from Predator 1 & 2).
I'd love to see a very gritty/grungy "90s" view of the future with characters that wouldn't look out of place in 2000ad comics, or a Rob Zombi / Spawn / Hardware / Crow City of Angels movie (that sort of feel). A total contrast from Naru, a sorta street-smart, greasy haired/cigarette smoking, ripped leggings, gun wielding ' take-no-shit survivor in the underworld with a bad attitude' kinda lead. (A female take on Rutger Hauer's character from 'Split Second'? maybe?) bad-cop vibes, with the narcotics taken from the Alien 3-esque scum in her territory lowering body temperature in the scorching apocalypse giving her an edge over the Predator.
Unlikely. But you know...
