I actually think they could do some cool stuff with the Super Predators mirroring the Paradise Lost elements of Prometheus.
I like to think that the Engineers are regarded as semi-mythical space-faring demigods by the Predators. There have been few interactions, but many Predators fear the Engineers and their fearsome dragon servants (xenomorphs). That is except for one clan, which, hundreds or thousands of years ago, became "fallen," cutting a deal with the Engineers for technology to genetically enhance themselves. These Super Predators also got Xenos from the Engineers, and used them in a war to try and subjugate the rest of the yautja. Eventually they were defeated and exiled to the hunting preserve.
I like this idea because it also has the benefit of re-imagining the relationship between the Predators and xenomorphs.