There'll be some kind of new angle. Can't help but wonder if we'll see a twisted human become a copycat Predator, or a Predator worshipper. Could be a clan member. It's been moving in that direction for some time. Noland used the tech. As did Dallas in AvP2. Edwin marvelled at their world. Lex had an unspoken bond, learned their ways. The cameo written for Dutch in Predators had him leading a Predator clan. That's a possible route.
Now, you could have that hero taking on someone from the Company's bio-weapon division. A villain who has enhanced himself with Alien genetics. There's your Blomkamp style AvP3 right there...