Structurally my mind visualizes the Prometheus sequel (as the continuing adventures of Shaw and David) as a much MUCH different kind of film than either Alien or Prometheus. I can see it being very difficult selling a film where the first 25 minutes are spent fleshing out how a human and a robot co-exist on an alien spacecraft in route to destination unknown.
The situation lends itself to being more cerebral with all sorts of messy emotional implications including but not limited to human/robot sexual deviations. (The actors themselves are no strangers to stressful, tense, even awkward sexual scenes.)
You've lost a bunch of the audience already ... but the remaining hour and a half should be a dissent into bio-mechanical madness. A sort of H.R. Giger fever dream that borderlines on the obscene but still clings to it's spiritual thread from Prometheus.
I don't want to see Avatar with Engineers. Or Aliens vs Predators Engineers. But I can see how in the wrong hands something like that could get the go ahead to grab that cash.