Yeah San Andreas fault line is about due for one. Its an inland fault line so most likely wont produce tsunami like in Japan. It usually quakes every 15-20 years or so and the last one was in '03 and are generally Magnitude 6 on average. I think the moons gravity may tip it. Im no scientist so dont take my word for it.
QUOTED from
http://en.wikipedia.org/wiki/San_Andreas_FaultA study completed by Yuri Fialko[9] has demonstrated that the San Andreas fault has been stressed to a level sufficient for the next "big one," as it is commonly called; that is, an earthquake of magnitude 7.0 or greater. The study also concluded that the risk of a large earthquake may be increasing more rapidly than researchers had previously believed.
..it also went onto write...
If such an earthquake were to occur, Fialko's study stated, it would result in substantial damage to Palm Springs and a number of other cities in San Bernardino, Riverside and Imperial counties in California, and Mexicali municipality in Baja California. Such an event would be felt throughout much of Southern California, including densely populated areas of metropolitan Los Angeles, Orange County, San Diego, Ensenada and Tijuana, Baja California, San Luis Rio Colorado in Sonora and Yuma, Arizona.
If anyone lives in these areas please just stay prepared.