I'm wondering if they'll continue as either Yautja or Hish (possibly the latter, considering it's the newest incarnation) or if they'll present yet another origin we'll have to deal with. After all, from the description it seems to be delving much more into Predators as an entire race as opposed to just small hunting parties, so it seems to me like one of these is to be expected.
Also, I'm curious to see if the supposed Predator remake (if it does indeed happen) is going to follow this same design scheme or try and keep it like the original movie.
As far as I'm concerned, any sort of continuity is dead and I'm just going with the flow. So, whatever they make them into is whatever they make them into. *shrug*