The franchise is really about the alien, and not counting the prequels (because they appear to lead to a reboot of the franchise probably given the assumption that most viewers are young and don't know about the first four movies because they were made a long time ago) and the predator (as having two antagonists complicates matters) we'd see one of the ff.
- the alien
- the hive, with queen and specialists
- aliens taking on some form of their hosts
- hybrids coupled with cloning and mutations
The fourth movie's too weird because it's no longer about the alien but all sorts of combinations, so I'd stick to at best alien hives. But what can one do that's new given that? For example, the IMDB entry generally refers to young people encountering the alien. That means it'll be just like the first four movies. In this case, though, it features young protagonists, like some from the prequels, and that'll be needed to make it a hit among younger audiences.
More important, if the prequels were made so because most viewers are young and don't know know about the first four movies, and if what they know about the franchise is dependent on the prequels, then this new movie will be dependent on the same, which means everything above, plus spores, Engineers, and more.
