Make it in the future. Long as it keeps in the future of 2100s, then I'm peachy keen. We already seen how using the modern setting not only doesn't work but the fanbase never wanted a present day story. Always been about offworld colonies, unknown worlds, colonial marines, and all that feeling.
Now if people wonder about using concepts from past films like the super predators, engineers, black goo, and all of that, guess it depends on the context of how it's used in the films. Super Predators isn't a bad idea on it's own, a rogue criminal element of Predator society that doesn't follow the rules of their people and wage war with other clans is a fine idea, just not fully explored as it could have. Black goo is also isn't that bad in my eyes, fits with how Engineers are that, engineers of making violent life in violent ways. Engineers from Prometheus.....tall pale bluish humans I still don't like it as much. The ancient astronauts idea just makes the Alien Universe that much smaller and keeps humans as "the chosen ones" aspect instead of humans finding out how scary and messed up the galaxy is and how we shouldn't mess around with what we don't know.
Just keep it in future space, that's all I ask for and I'm good, please!