Predator RPG... maybe spanning over the last few centuries, or for however long a Predator lives. Your character can grow with it's technology, and in turn shed a little light on Predator culture. Missions could take place on different planets, maybe something like Mass Effect, where certain worlds might be infested with Aliens, or any of the creatures shown in the trophy rooms in Predator 2 and AVP Requiem...and you can fight them in real-time (none of that turn-based crap). Maybe some Space Jockeys could be thrown in for a nice bonus mission. Personally, I'd like it to be a precursor to the first Predator movie... maybe the game could end with your character setting course for South America.
Just an idea.