As a whole, I thought the story was downright garbage. It was so implausible it actually ruined the game for me.
I thought the parts with the predator hunting down the Mafia in the 1930s were actually kind of cool, but then it all went downhill fast.
Scarface sets off his self destruct, which obliterates the entire city, yet he somehow comes out unscathed. He is dishonoured for revealing the existence of his species to mankind (uh...wait, isn't nuking a city a good way to eradicate evidence according to every Sci-Fi movie ever made..?) & is sent to a barren planet in exile for 100 years.
Flash forward to 2030 & Scarface is still standing there, in the exact same spot, looking like he has just finished his lunch break. In all this time, humans have somehow dig up his mask & combistick out of the rubble of a nuked city (errr...what the f**k?) & created an entire new, space-age metropolis. I'm calling bullshit right there on the very premise. How did he survive the nuke, how did humanity salvage a couple of tiny pieces of gear out of a city that had been totally destroyed?
Anyway, moving on. Coming back to Neonopolis, the predator has to redeem himself for the 'sins of his past' & sets about hunting down all the criminal gangs who are using the stolen Prometheus technology. First it's the Serviteurs, cheap knock-offs of King Willie's goons from Predator 2. Then the Deadmen, drugged-up like walking zombies, & finally the Mafia itself. Along the way Scarface fights against giant mech suits & crack heads who jump around like Wolverine with metal blades on their hands. Already this is playing out like a total cartoon.
Los Matadores begin taking over the city. A gang who consist entirely of Lucha libre wrestlers led by Chavo Guerrero, (aka: El Hongo). After the predator kills all their pimps & whores, Chavo Guerrero pleads for help from Lucretia, the scary boss lady, who unleashes a bunch of cybernetic Terminator-inspired freaks onto the predator, who are killed in short order.
Chavo, now shitting his pants, seeks refuge at a black market arms deal, run by--wait for it--ex porn stars turned hookers. Now we've really gone off the deep end. The predator murders everyone, busts into Lucretia's compound & then gets his ass kicked by about 100 cybernetic Terminators.
After being captured, he finally breaks out of the research labs, fighting against robotically modified bad bloods & Ronins (aka: Samurai) before finally reaching the lair of MOTHER, the supercomputer controlling the city. She is actually the remnants of Isabella Borgia, the woman who shot Scarface through the eye 100 years ago. Some piss-weak aliens show up out of the blue & get stomped on like bugs, because apparently Scarface is invincible. He kills MOTHER & goes after Hunter, the son of the Mob boss he made a trophy of 100 years ago, who has now genetically modified himself into a predator-human hybrid. If you can keep a straight face by this point, then you must be made of stone.
Scarface then aligns himself with the Samurai Ronins to fight Hunter Borgia, who uses predator weapons by the way, & finally decapitates him. End of story, he goes home. Now this has to be the worst predator team-up ever. Scar & Lex in AVP was bad enough...but teaming up with a trio of Samurai? That is just comedy right there.
Credits roll, reference to Weyland Yutani Corp. etc. Total missed opportunity.