Maybe, just maybe in the sequel if its still set with the Comanche, 2 Different feuding factions of predator species arrive and one could later side with Naru in defeating the other/s and then acquire the flintlock pistol from Naru, who knows the possibilities are endless.
I read somewhere they might even do the sequel in ancient Japan with feuding Samurais. Predator as a concept can do well very well in different locations and settings.
I was also thinking of, what if the predator gets dropped in Africa imagine a fight with a male African lion on the Serengeti plains...rocking!!:)