Since the announcement of the new movie, I think we will get one, but it'll be a while because of the sting of Colonial Marines. I think Isolation helped to alleviate this, though. One of Colonial Marines's great weaknesses was that it treaded old ground. LV-426? Sulaco? Hicks is alive again through the worst retcon I've ever seen? Yawn! Couple that with Gearbox's lack of care and incompetence and you get a shit game.
Set the new game someplace new. Any place that's new. Make it take place aboard an asteroid colony, a jungle world, a space station then tracking them down to a jungle world. ANYTHING that doesn't just feel like it has a leash around its neck because it wants to shackle itself to Aliens. Oh, and give it to a competent studio this time.