Oh. I read another article based on this interview and it showed presented she said in a much more positive light. Having seen this whole video it now seems as if she's not really that interested. She's just not closed-minded about it.
I think if it happens, it will likely be bad, and it will probably mess with the previous content.
In terms of an unrelated film - I think that will be quite ignorable. The only reason a sequel is really asked for is so that it can be added on to the story of Ripley. Of course if it is an unrelated film, and it is destructive of previous content, it will easier be able to be ignored, than if it was part of the series.