Whitehall could perhaps come back. He has Daisy's mother's Inhuman DNA that could have don't something to him.
I think he's dead, though. They set him up so you think he's the big bad, but then he winds up just paving the path to the Inhuman stuff. His origin, his experiments, all of it leads back to that. So I'm guessing we're going to have an Inhuman or alien (perhaps Kree) provide the direct threat in the second half.
I wonder if Raina is going to be a villain or take SHIELDs side. Or neither, like she's been doing. Really interested in seeing how she and Daisy (still not used to that
) react to their changes.