Wow this thread is a tough read for good news. My bullet points.
1) What could you possibly do with "Predators" sequel but do the exact movie over again? No.
2) It's clear they don't want to follow anything from Predator 2 , numerous movie's prove this. No
3) Why would you suddenly throw a large amount of money at something that will make the same regardless? No
In my opinion this "reboot" may actually be a reboot. My initial guess would be that they replicate the original story with new characters and perhaps some slight differences, like two hunters instead of one, a different location and a female lead.
That's my bit for now, interested to see how this unfolds.