Ive been thinking about the SJ POV of things. They've already mastered things on the nano level. So over time their "plans" and line of thinking would be more MACROscopic instead of MICRO. This is their downfall though. Life finds a way. Like a virus, one rogue jockey infected them, and enchanced himself with the products (gene therapy).
When i think of the Prometheus heading to LV223, im thinking its like a sperm heading for an egg. (does the sperm know it will "die" and pretty much the only part left of it will be the combinations of its genetic data that SURVIVES the merger between itself and the egg's data?) most likely not.
The entire process of them going there is to create a new being or the next step of evolution. The crew (shaw) thinks they are going there for their own benefit and in a way they are.....but in truth, not for human reasons. (Not anymore atleast, not since the "betrayal", more on that later). I think what we have is one Jockey who is hellbent on creating a being, or merging itself with ALL dna's possible, hence the urns (trophies). He experimented on his crew members and they died (except one who got away), and has turned what was a garden into hell. He just waits for species to come there. He poses as God to the beings that arrive much to their demise. He is trying to become God by literally becoming made up of all things, Biological,Mechanical,and Spiritual. Just like an Android wanting a soul....to be human.
Its possible that human dna is a missing piece he's looking for (spirit)(ironic we are there to look for our missing piece) and decides to head to earth after witnessing their arrival, to "Harvest" it. ALL of it. He probably has done this lots of times to all the beings that he has urns for. Each of those planets on the SJ holo map are the DNA's/ worlds he has "conquered"/cataloged.
David or Weyland is our him and the same betrayal that the SJ commited is played out before our eyes with the humans. I think Vickers has knowledge of a beacon saying to stay away (LV426) but is not telling anyone directly because her mission is the same as Ash's was.
Its possible the Jockey that we meet is actually a Xeno Jockey and is NOT our true MAKER or SJ, they all died after his birth. He is the "King" Xenomorph. Weyland is all about this mission because he thinks he can actually pose a challenge to the King and take what he wants in one fell swoop instead of earning or actually gathering the data planet by planet as the SJ's did. The King did to the SJ's what Weyland is trying to do with him. ARROGANCE and THEFT.
He wants what we got and we want what he's got. The product of all of this? Internecivus raptus A murderous thief.