Probably not final but the names suggest a more Legion orientated approach than Fargo, often that the character's names in it said something direct about what they are. Examples Cary and Kerry, Syd and Switch come to mind.
I hope he does his usual of reusing actors and we get Hamish Linklater and others such as Navid Negahban.
Both as of recently also have superb experience playing cult like leaders.
Spoiler
With monsters.
Bill Irwin I'd also like to see as a scientist once again. I'd advise against Amber Midthunder returning, with her being in Predator Skulls and all, but then again the late great Bill Paxton starred in both an Alien and Predator film so who knows really...
As for the whole, woman playing a man, that's in reality a woman in a man's body thing, that does not sound as completely out of nowhere for people who have read Alien The Cold Forge and have experienced Noah Hawley's Legion.
Amahl Farouk in that has had multiple actors play the part male and female, whilst still being completely a man, it's difficult to explain without watching it yourself.
In the first Season he's mainly played by Aubrey Plaza whilst she's trapped inside her body. Then onwards, he's also played by Jemaine Clement, whilst also Aubrey Plaza, whilst truly represented by Navid Negahban in the second and third seasons.
No "transition narrative" present, in any of this, but he's done this kind of thing before's really my point, and it does not make sense until you see it visually presented.
Although I am very much up for a trans narrative in Alien and think it's been a long time coming.