While Deadline wasn't able to go into specifics of the plot of Predator 5, we do actually have some story details for you! Alien vs. Predator Galaxy has known about this upcoming Predator 5 for a little while now. Now bear with us on this one because it is going to seem like a leap.
In December of 2019, Discussing Film exclusively announced that Trachtenberg was developing a film with 20th Century Studios and Disney called Skulls, also written by Patrick Aison and was to be producer by long time Predator series producer John Davis. Discussing Film also provided some small details about Skulls' plot.
Quote'Skulls' will follow a Comanche woman who goes against gender norms and traditions to become a warrior.
This small bit of information marries up with what Alien vs. Predator Galaxy was told regarding the upcoming Predator 5. According to our own sources Predator 5 will be set in the past (finally!) where it will focus around Native Americans before the territories were taken by the American settles, featuring a First Nations cast. It seems quite likely that Skulls is actually Predator 5, perhaps a working title or codename.