The Fugitive Predator was not on Earth to break bread, to make peace with humans. He didn't come to become friends, to sign a peace treaty and promise to never hunt or kill. The Fugitive just came to stop our extinction by a dishonorable rogue clan.
The humans the Fugitive killed had him literally strapped down to a table and were yelling and panicking in a fenzy. The Predator is an intelligent creature. He probably realized what this was: Captivity. Humans that wanted to study him, poke and prod, steal his tech. No honorable Yautja is going to be some government trapped lab rat, science experiment. F*ck that. So it had to escape by any means necessary.
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