It depends on what timeline you go from, if you go from the movie timeline you've still essentially got the main cast from JP and Lex and Tim will be grown up, as well as possibly incorporating Dr. Wu into the storyline. If you go with the book storyline, you've still got a few people from the original JP, although TLW told us that Gennaro dies after surviving in the book, Muldoon could return, as he survived the book and i dont remember anything being said about him in TLW, although Hammond is dead and the the people from Biosyn as well, but they would probably just go with the movie continuity, which annoy me as i felt that if the book had been copied amost exactly it would of been even better than it was.