In addition to Mass Effect 4, a couple of potential spiritual successors to Mass Effect in the works:
https://humanoidstudios.com/ "By combining excellence in the arts with innovative technologies, videogames have the extraordinary power to transport you to new worlds of adventure. That's what first inspired me to make games, and it's at the heart of what we do at Humanoid Studios."
Casey Hudson, (Creative Director for the original Mass Effect Trilogy and KOTOR) Founder & CEO
https://www.archetype-entertainment.com/ Archetype Entertainment is a game development studio in Austin, Texas led by industry veterans from BioWare and other AAA studios.
"Archetype is a chance for us to build the type of roleplaying game that we love to play. Video games are a uniquely interactive medium. They allow us to give the player powerful choices that have real consequences on how the story unfolds." -James Ohlen, (Design Director of Dragon Age Origins and KOTOR) Head of Studio
Also attached:
https://drewkarpyshyn.com/c/?p=1089Worth keeping an eye on, I'd say.