I don't see the idea as Monster of the week, more for the thing to skit an episode or how many the particular story deserves per story on key blanks between films that we've got questions to & where we are by default already somewhat emotionally invested via the films.
You could interweave Easter eggs or connections between different stories across the decades of the Alien timeline, would be awesome and much to riff off to get started
Eg) A Peter Weyland story,
The murder of Elizabeth Shaw,
David on the Covenant experimenting on the colonists with a failed escape by one of his victims,
Alien Isolation story,
River of Pain,
Alien 3 egg