I'm thinking more along the lines of what was done in the AVP3 WORLD WAR comic series. The Predator race known as the Killers had bred a type of alien/predator hybrid that was tamed only by them. Imagine if that was taken a step further and human dna was thrown into the mix ,if it was done just right, creating a crazed new hybrid that would resemble a mix of all three species. This could only happen if say the aliens that it was spawned from a race of hybrid queens, but nothing like the one seen in AVP-R, something more bad- ass.
