Push the creator, creation angle even farther by revealing the SJ's created the Engineers eons ago, some cataclysm happened and they disappeared. They discovered the Alien, it destroyed them. The Engineers, millennia later inherited their technology.
The Pathogen, which the SJs derived from the Alien, somehow (the audience isn't told) is all that remains of that Galactic extinction event. Ruins, and technological remains. The SJ's wanted to fight fire with fire with the Pathogen, but the Pathogen- although destructive to worlds- couldn't infect or best the Alien. In fact it always worked it's way towards something resembling the Alien more and more with each use. All the Space Jockey's race die, all but a few. They're effectively extinct.
So the Engineers, in their hubris- flying too close to the sun, make the same mistakes in using this almost "seductively" powerful Pathogen, believing they can control it- it leaves their civilizations in ruins LV-223 being the source of the main disaster, which they abandon. So obviously they banish the Wolf, undo their creation but in the process become the insular and primitive society we see in Covenant.
David gets the wrong end of the stick, believes he's creating something original but in reality it is guiding him to almost supernaturally, resurrect the Alien from extinction.
He would realise this when he discovers the Derelict, or the Derelict discovers him- and that would be his grand downfall- not just physically but mentally.
