PREDATORS was meant as a "reboot" but not in the sense of a remake. Instead, its a reboot, in the sense of; a new movie. It was to be a jump-start to begin a new series of movies in the ongoing PREDATOR franchise. Nothing was ever meant to be replaced or destroyed. Ignored, creatively, yes. No one in the production wanted anything to do with the AvP's. For obvious reasons. So PREDATORS is a reboot, just a constructive one.
I do feel like the sequel will focus on the feud. Likely with Royce and Isabelle, along with new survivors, getting caught up in the middle. Since they're getting a bigger bidget for the sequel we may get to see whole groups of Preds, classic and super, going at it. Or maybe not. We'll have to wait and see.
Titles i was thinking about, terrible and basic;
PREDATORS - Blood War
PREDATORS - War
PREDATORS - the Hunt
PREDATORS - Nemesis
PREDATORS - Death
PREDATORS - Endgame
As far as any future AvP's go; not anytime soon.