So, "God, please give me the strength to be there for my mother as the cancer you gave her slowly kills her" is your typical kind of prayer then? You realize that when people pray it's very similar to just reassuring themselves. I'd consider it more plausible that they are trying to kick their mental fortitude back into gear, rather then conversing with a mystical being whose response would be impossible to tell apart from happy coincidence.
However one tries to explain prayer, there's always a leap required to get to God. You can explain how it works, what's a valid prayer and what kind of response you can expect, but the 'and then it gets to Yahweh' part always requires a leap.