The processor tells you that something is actually wrong here:
Do as in the picture but I advise you to change the following:
*Uncheck "Fast Approximation" since you want to know if optimization work.
*Put in project directory instead of the very complicated and likely buggy line this:
..\AVP2
(Assuming the unrez AVP2 folder is in the Aliens Vs. Predator 2 folder).
*Extra parameters: -nosnapnocsg
Since it's better to create a map using the one-sided technique (processing is faster, visibility is clearer and less messy in DEdit) you not gonna need the leakfile since those doesn't work.
Good luck
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EDIT:
Also, in the Run Option dialog, don't forget to put the correct path to everything (lithtech.exe is located in the Aliens Vs. Predator 2 directory) and be sure to know where your "AVP2" unrez folder is cos you might want to edit your "-rez" call command.
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EDIT 2:
Did you add a Gamestartpoint inside your room and a worldproprities object? They are the two basics required to run a map.