I am ok with a PredAlien Queen, so long as her Design does not differ too much from a regular Queen.
Take the Queen from AVP design, make her 1/3 rd bigger and ad mandibles to her mouth piece.
Other than that, the only thing the NEEDS to be correct with her, is that her eggs (2nd gens) need to start with a clean slate again.
No Pred traits getting passed down to Aliens from human hosts from a PredAlien-Queen.
Then I am ok with it.