It still bugs me more than anything when 'they' make these cliffhanger endings like direct sequels are a certainty in these franchises.
If you're not in the middle of making the next Marvel/DC/StarWars, you shouldn't over estimate your chances of setting up more films that need to explain or conclude your story.
I haven't seen The Predator yet, but from I could gather from comments I've read, non of the alternate endings makes sense. Especially if you are not considering having Ripley and Newt from an alternate timeline come back to the 21st century to fight Predators and Aliens.
Just leave Ripley and the Yautjas on earth stories be. Ripley is dead and Predators on earth are boring by now.
I want to see an adaptation of the first Aliens versus Predator storyline from Dark Horse.