I'd love for Alien5 with Weaver to step in front of any potential AVP. I think to a lot of people it would be redeeming after the dissatisfaction of the two AVP movies, plus with the recent trend of bringing back old movie characters, now would seem the right time. As for a director, I think perhaps we should accept having either Ridley Scott of James Cameron on board is pretty unlikely... there are surely other candidates who could do a good job.