I think it's possible for two correlating series to be about different things whilst existing in the same universe, without characters directly crossing over or effecting each other in fact- I think that's an interesting idea. I'm not saying that Alien and Blade Runner do but they easily could, as much as Prometheus with memory viewing technology and Aliens can co-exist, where they doubt Ripley's story.
Unless that technology was lost with the Prometheus and it was also a scientific research platform as well as Peter Weyland's luxury yacht, the same could be done to work around any potential inconsistencies between Alien and Blade Runner.