I don't have much problem with the company being cartoonishly evil enough to infect a colony on purpose. I'm pretty sure they sent the Nostromo near LV-426 and colonized it just to sacrifice employees for specimens anyway. I'm even more certain of this after the Advent short film. They knew David had created something terrible out there and they wanted it.
My problem is that Aliens: Resistance has to take place before Aliens. It would be fine if it took place after Aliens, but if Amanda Ripley is still alive, it must take place before.
So W-Y completely contained the aliens, bred them in captivity, and bombed a colony with them for research. This paints the company as being way more resourceful, capable, & knowledgeable than they appear to be thirty years later in Aliens. Doesn't make sense.