It's not really about the setting, though I'd love some desert action, but about the plot.
My main problem with Ps is not about what it rehashed from P1(even though it was annoying) but what it teased and didn't deliver ("Shit you wouldn't believe" and we don't, cause we haven't seen any).
What I'd love to see (and I've been saying it for years) is reversed scenario. Make Predator on the run. Show us super prepared human task force with equipment and man power to actually go after predator. Go big! Give them tanks and choopers! Make the creature vulnerable, wounded and chased. Then reverse the plot again and show us the Predator live up to its name! Garber was told he'll get another chance and I want this chance taken.
What I don't want to see is autistic kid decyphering Predator symbols. It's stupid. Autism is a disease. Just like jumping into toxic waste, it doesn't give you super powers, just makes your life harder. You know what. Make kid straight forward psychic, like Forest Whitaker in Species. It's as unrealistic as autism superpowers, but much less convoulted.