Yes, if they had made it clear that externally she looked human but internally she had the complete structure of an Alien and the muscle and bone of them, bar the obvious shape like the head etc, then its less jarring but then how realistic is a crossing like this? Hybrids do exist i.e Ligers and Tigons but that is from a more natural method...so to speak, would cloning really do this?
See from my point of view, the Aliens seriously started off realistically, and avoided going to in depth into tech to keep it ambiguous such as how space travel worked etc.
Resurrection just doesn't have that tone, Ripley 8 is not the only ridicules thing in it.
I enjoy Resurrection for what it is of course, it is a fun film when like it for its merits and mindless fun, but its no Alien film to me, a parody at best.