Shit, it wouldn't even work for a singleplayer 'Alien'-themed game.
The ship's layout as seen in the movie worked fine for a movie, where the filmmakers had complete control over the characters, the Alien, the lighting, the camera locations, everything.
If you're making a video game where you don't have absolute control over the players' actions, they'd end up breaking things that maintain "the immersion" anyway, especially if the setting is 100% accurate to a movie that didn't have the variable of player free-will.
Actually I'll amend that, it wouldn't even work for a singleplayer 'Alien'-themed game, unless the player was playing as the Alien against AI-controlled humans. Then you could conceivably make it 100% accurate to the movie and player randomness wouldn't exactly be as big of a factor, since as the Alien every time you ran into a human you'd conceivably butcher them anyway. If you were forced to play as a human and be stalked by an Alien, though, players would find ways to break the immersion almost immediately. Definitely better to make a Nostromo "inspired" level with level design conceits tailored to the actual gameplay.