I love the new setting and i quite liked 10 Cloverfield Lane, although one movie is not enough for me to fully evaluate Trachtenberg's skillset. A female lead doesn't bother me at all as long as she is well written and portrayed, like any character in any movie.
For the predator itself, i hope they go for a "different" look (not too different though), a more tribal look, like we can feel it was a few hundreds years ago.