I think I was immune to the dopey guy in the new beginning because I had seen a Jeunet film before where the actors made quirky odd movements. As a matter of fact, if you watch La cité des enfants perdus you'll notice a lot of elements that Jeunet borrowed for A:Res such as the cloning vessels, the gunky technology used on Vriess's chair, a demented scientist in green surgical garb, and a girl plummeting into the water. Let's not forget the two actors Dominique Pinon and Ron Perlman.
I will agree though that the animation used on the extreme close-up of the bug was dodgy at best considering the digital fleas were rendered much better, and those were done back in 1995.