For the sake of storytelling, I rather not have an Engineer/Predator war, rather have them come across each other for the first time on screen. I did like how Fire and Stone treated the crossover of the two species of Ahab searching and studying the Engineers. However the panels were slightly shallow and would be interesting to see their initial meeting. How do they feel, think, react to each other. It was like the moment to how the Engineer in Prometheus interacted with Weyland and company, what was going in its mind when it encountered humans for the first time and what could have changed if Weyland didn't demand for immortality? The fact that it didn't kill them right away up until Weyland demanded for immortality indicated that things could have gone much more smoothly. No more war scales, The Predator executed that idea of a human/ Predator war terribly, I want none of that.
Elements of Prometheus can exist in the AVPverse, as the concept themselves are not exclusive to Alien themselves. After all, if Fire and Stone is to go with, it seems like the events of AVP/AVPR never occurred, therefore implying the Prometheus version of the Weyland origins is the dominant canon. One can say the same for the AVPverse, where the Prometheus Weyland origins never occurred, Yutani has the plasma pistol in their possession, and you can build off from there.
Now, I am wondering if any new upcoming lore from Hunting Grounds will alter the course of the AVPverse, seeing how both timelines coexist with each other. Like say with the presence of Predator technology, will it really alter human tech and things to come in the future. I recall that the plasma rifle in Colonial Marines is canon, hinting that maybe it is derived from Pred tech? Not to mention that if experimental medical treatment enabled Dutch to gain immortality, how else can this new tech be explored in future stories?