I can imagine a "Event Horizon" kind of situation where a ship that left the station is being hailed by another ship and is not getting an response, the other ship then docks via umbilcal and a team of non-marines board and investigate. There will be a slow build up with nothing happening at first, with the team only finding that the ship appears to be empty. No bodies and none to little blood and then at some point, a hive is found and then crap hits the fan and whoever survives manages to escape after setting the ships course for the nearest sun, unfortunately the umbilical is used by Xenomorphs to hitch a ride on the other ship which would be half-way through the game and then you have try to either find a way to exterminate them or make for the escape pod. Just the top of my head.
The more I think about it, a ship idea sounds intriguing.