While I agree it would've sold worse, some aspects of AvP:R are still there.
The main Predator(Wolf in AvP:R, I believe it was named Dark in AvP2010) goes to -insert planet here- because of an Alien infestation
The main Pred soon learns that one of his fallen comrades is infected with the chestburster, thus creating the PredAlien
The "big baddie" of, atleast the Pred campaign in the game, is the PredAlien
The PredAlien in the game is clearly heavily inspired by the Chet
I would say that Wolf is a boss and multiplayer skin aswell, but I don't think that counts. Thats more of a homage.