If it was done really well then it could be great. Concrete Jungle felt like a better version of what the AVP movies were trying to do, although there was still that feeling of "wait, really?".
I think we can all agree a large scale Predator game that featured full customization and that allows you to go to various planets and fight a growing list of creatures would be cool as hell. And a really great story, and......ramble ramble. We all know what we want.