Question is, would a sequel follow Scarface (ala Riddick in the sequel to Pitch Black), or follow Lucretia & the Weyland-Yutani merger, & their interactions with other Preds?
I don't think there's really a scenario where you could incorporate both ends here. Either you go in one direction, following Scarface to other worlds, or you start as a new Pred altogether, battling Lucretia as the new MOTHER, & essentially do the whole thing all over again, with different technology & foes.
I had a storyline idea much like the 2nd scenario except it was more of an open world. Basically, Weyland-Yutani somehow got access to Hunter's experiments somehow and decided to use Lucretia for a soldier experiment in order for humans to successfully obtain Xenomorphs without harm. I had Scarface as your Elder in the clan and it took place shortly after Alien 3. I had started some creature ideas for the Predator to hunt. In order to progress in the storyline, you had to do a number of hunts in order to gain experience.
I had the idea somewhere, I should post it up sometime. It would involve different hunts besides just humans and Aliens.